Gout is an inflammatory arthritic condition that occurs when urate crystals accumulate in joints and other tissues.
It is the most common form of inflammatory arthritis in men with an overall prevalence in UK general practices of 1.4%. Both the incidence and prevalence increase with age.
More than 7% of men aged over 65 years and around 2.3% of women aged over 65 years in the UK are affected. The male:female ratio is at least 4:1, women being affected less frequently than men because of the uricosuric effect of estrogens.
Population studies from both the Mayo Clinia and from Taiwan have shown significant increases in the prevalence of gout compared with 20 years ago. This may be partly explained by increased life span, obesity and use of diuretics.
Pathogenesis
Hyperuricaemia develops either due to over production or under excretion of uric acid. Asymptomatic hyperuricaemia is common and can persist for many years before gout occurs. In patients at risk of developing gout, an acute attack may be precipitated by acute illness, excessive eating, heavy alcohol intake, dehydration, rapid weight loss or recent surgery.
The majority of patients go on to have recurrent flares; 62% within one year and 89% within five years. When untreated, advanced gout develops causing damage and deformity at multiple joints, the development of large tophi and in some cases renal stone formation. Advanced polyarticular tophaceous gout can mimic severe rheumatoid arthritis.
Risk factors
The risk factors for gout can be divided into modifiable and non-modifiable. The non-modifiable risk factors for gout are age, sex, race, genetic factors and chronic renal failure. There is a familial tendency and 30% of patients have at least one relative with gout. In the UK Health Improvement Network (THIN)5 study risk factors for gout were evaluated .
Hyperuricaemia is the strongest modifiable risk factor for gout. The incidence of recurrent gout attacks is strongly related to serum uric acid (sUA) concentration. Reduction of sUA to ≤0.36 mmol/l eventually results in prevention of future gout attacks.
Obesity is not only a risk factor but is associated with an earlier onset of gout. In the CLUE II study the mean age of gout onset was 3.1 years earlier in those who were obese at baseline and 11 years earlier in participants who were obese at age 21.
http://www.mycme.com/managing-gout/material/715/2320/